News & Publications

Publications

• "Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry" (PDF)
  
  
• "Functional Interrogation of the Kinome Using Nucleotide Acyl Phosphates" (PDF)
  
  
• Nomanbhoy TK, Rosenblum J, Aban A, Burbaum JJ. Inhibitor focusing: direct
  selection of drug targets from proteomes using activity-based probes. Assay Drug
  Dev Technol. 2003 Feb;1(1 Pt 2):137-46. PubMed PMID: 15090140.
  
  
• Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET,
  Nugent RA, Nomanbhoy TK, Alexander JP, Cravatt BF. Novel mechanistic class of
  fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry.
  2007 Nov 13;46(45):13019-30. Epub 2007 Oct 19. PubMed PMID: 17949010.
  
  
• Liu Y, Shreder KR, Gai W, Corral S, Ferris DK, Rosenblum JS. Wortmannin, a
  widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian
  polo-like kinase. Chem Biol. 2005 Jan;12(1):99-107. PubMed PMID: 15664519.
  
  
• Liu Y, Jiang N, Wu J, Dai W, Rosenblum JS. Polo-like kinases inhibited by
  wortmannin. Labeling site and downstream effects. J Biol Chem. 2007 Jan
  26;282(4):2505-11. Epub 2006 Nov 29. PubMed PMID: 17135248.
  
  
• Okerberg ES, Wu J, Zhang B, Samii B, Blackford K, Winn DT, Shreder KR, Burbaum
  JJ, Patricelli MP. High-resolution functional proteomics by active-site peptide
  profiling. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4996-5001. Epub 2005 Mar
  28. PubMed PMID: 15795380; PubMed Central PMCID: PMC555687.
  
  
• Patricelli MP. Activity-based probes for functional proteomics. Brief Funct
  Genomic Proteomic. 2002 Jul;1(2):151-8. PubMed PMID: 15239901.
  
  
• Patricelli MP, Giang DK, Stamp LM, Burbaum JJ. Direct visualization of serine
  hydrolase activities in complex proteomes using fluorescent active site-directed
  probes. Proteomics. 2001 Sep;1(9):1067-71. PubMed PMID: 11990500.

Press Releases

• "Thermo Fisher Scientific Licenses Novel Activity-Based Protein Profiling Technology from ActivX Biosciences, Inc." (PDF)